I like the feel of a big book in my lap, it reminds me of the Andy
Divine T.V. show 50 years ago. Andy would start the show siting
in a chair with a big book open in his lap, His magic frog would,
"plunk his magic twanger", and the story would start.
This summer I read a big book, a bio-chemistry text book that
was copyrighted in 1995, the book I used when I took bio-chem
in the 70's was probably copyrighted in 1975. (I may be the only
person in the world who, two months from retirement, read an
entire bio-chem test, cover to cover). Much of it read like science
fiction, it has been 25 years since I took bio-chem in collage and
much has changed.I did not read it just to catch up on current
science, I also read it to see how it would change my world view,
as stated in the archives of this blog.
One of the changes was in the ultimate complexity of proteins,
20 raised to the power of the number of amino acids is only part
of the total variation in proteins. Variation is increased by: post
translation modifications, as in glycoproteins, and side chain
additions; also the incorporation of organic molecules and
metallic ions increases the complexity of final conformations.
There was also a reduction in complexity because, two proteins
can have similar conformations and functions with only 20% of
there amino acid sequences being similar. The change that I
enjoyed the most in this newer addition were the many
references to evolution, especially the references to an RNA
world which preceded our present DNA world. One striking
example of self-splicing RNA, was a ribosomal RNA precursor
that could prune and splice itself to its final form.
Well, I’ve started another big book, I’m reading,
Stephen Wolfram’s book "A New Kind of Science", again,
1197 pages in all.